BM2021 BIOFLUIDS AND DYNAMICS Lecture Notes for BME - Sixth (6th) semester
BM2021 Lecture Notes
UNIT I BIO-FLUID MECHANICS
Newton’s laws, Stress, Strain, Elasticity, Hooks-law, viscosity,Newtonian fluid,
Non-Newtonian fluid, Viscoelastic fluids, vascular tree, Relationship between diameter,
velocity and pressure of blood flow, Resistance against flow.
Viscoelasticity - Viscoelastic models, Maxwell, Voigt and
Kelvin Models, Response to Harmonic variation, Use of viscoelastic models,
Viscoelastic fluids: Protoplasm, Mucus, Saliva, Synovial fluids.
UNIT II FLOW PROPERTIES OF BLOOD
Physical, Chemical and Rheological properties ofblood. Apparent and relative viscosity,
Blood viscosity variation: Effect of shear rate,hematocrit, temperature, protein
contents of blood. Casson’s equation, Problemsassociated with extracorporeal blood flow.
RHEOLOGY OF BLOOD IN MICROVESSELS
Fahraeus -Lindquist effect and inverse effect, distribution of suspended particles in a
narrow rigid tube. Nature of red blood cells in tightly fitting tubes, hematocrit in very narrow tube.
UNIT III CARDIAC MECHANICS
Cardiovascular system. Mechanical properties of blood vessels: arteries, arterioles, capillaries
and veins. Blood flow: Laminar and Turbulent, Physics of cardiovascular diseases, Prosthetic
heart valves and replacements.
Alveoli mechanics, Interaction of Blood and Lung P-V
curve of Lung: Breathing mechanism, Airway resistance, Physics of Lung diseases.
UNIT IV SOFT TISSUE MECHANICS
Pseudo elasticity, non-linear stress-strain relationship,
Viscoelasticity, Structure, function and mechanical properties of skin, ligaments and
UNIT V ORTHOPEDIC MECHANICS
Mechanical properties of cartilage, diffusion properties of
Articular cartilage, mechanical properties of bone, kinetics and kinematics of joints,
lubrication of joints.